Vaccine Spike vs. SARS-COV-2 Spike

Vaccine Spike vs. SARS-COV-2 Spike

Vaccine Spike vs. SARS-COV-2 Spike

There has been a lot of discussion for the spike and ACE2 binding. I have recorded many talks on this topic as well. However, an important piece missing for us has been to understand the difference of the spike between the vaccine and the virus. Let’s review these differences.

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URL list from Thursday, Nov. 17 2022

DrBeen: Medical Education Online


SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies | SpringerLink

SARS-CoV-2 structural features may explain limited neutralizing-antibody responses | npj Vaccines

SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic | Signal Transduction and Targeted Therapy

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen | PNAS

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report | NEJM

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes – PMC

SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern | PNAS

Frontiers | Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

Closing coronavirus spike glycoproteins by structure-guided design – PMC

Prefusion Coronavirus Spike Proteins and Their Use | Technology Transfer

Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine – UT News

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets | eLife

Epitope – Wikipedia