Vaccine Spike vs. SARS-COV-2 Spike – Part 2

Vaccine Spike vs. SARS-COV-2 Spike – Part 2

Vaccine Spike vs. SARS-COV-2 Spike – Part 2

In this part 2 we will discuss the long COVID like pathogenesis from vaccines and the potential etiology while the spike is locked in prefusion (S-2P) state.

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Sunday, Nov. 20 2022

RBD does not bind in the down position.
Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full

Excerpt:
To date, NAbs targeting SARS-CoV-2 RBD have been classified into four structural groups, C1-C4 (Figure 1), based on their ability to bind to up or down conformations of the SARS-CoV-2 RBD, and by their overlap with the ACE2 binding site (17). The C1 class is defined by NAbs that bind within the RBD ACE2 binding site, essentially mimicking ACE2 binding, and thus only bind to RBD when it is in the up conformation. The C1 class contains conserved ACE2-blocking NAbs, often composed of heavy chains encoded by the VH3-52 and VH3-66 gene segments (25). C2 NAbs block the ACE2 binding site yet can bind to RBD in its up and down conformations. C3 NAbs bind largely outside the ACE2 binding site of RBD in both up and down conformations, while a fourth class (C4) binds farther from the ACE2 binding site and the epitope is only accessible once SARS-CoV-2 S undergoes large conformational changes (30). Overall, a variety of NAb/RBD structures have been completed and their interactions defined (see refs. in Table 1).

Viral targets for vaccines against COVID-19 | Nature Reviews Immunology
https://www.nature.com/articles/s41577-020-00480-0

fimmu-12-691715-g001.jpg (1242×734)
https://www.frontiersin.org/files/Articles/691715/fimmu-12-691715-HTML-r1/image_m/fimmu-12-691715-g001.jpg

mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants | Scientific Reports
https://www.nature.com/articles/s41598-022-06629-2

Vaccines | Free Full-Text | Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review
https://www.mdpi.com/2076-393X/10/6/909/htm

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes – PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302215/

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice – eBioMedicine
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30573-9/fulltext

Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full

A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/10.1056/NEJMcibr2113694

Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMc2119443

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans | Nature
https://www.nature.com/articles/s41586-021-03647-4

COVID‐19 and plasma cells: Is there long‐lived protection?* – Nguyen – 2022 – Immunological Reviews – Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/imr.13115

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